Protein Details: G protein-activated inward rectifier potassium channel 2

Protein ID

ICDB_Pro_0552

Protein Name

G protein-activated inward rectifier potassium channel 2

Gene Name

Kcnj6; Girk2; Kcnj7; W

Organism

Mus musculus (Mouse)

Length

425 amino acids

AlphaFoldDB

AF-P48542-F1-model_v4.pdb

Function

This potassium channel is controlled by G proteins. It plays a role in granule cell differentiation; possibly via membrane hyperpolarization. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Sequence

MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQSDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGIVEATGMTCQARSSYITSEILWGYRFTPVLTMEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAEVPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV

PDB Structures

2E4F 3AGW 3AT8 3AT9 3ATA 3ATB 3ATD 3ATE 3ATF 3AUW 3SYA 3SYC 3SYO 3SYP 3SYQ 3VSQ 4KFM 6XEU 6XEV 6XIS 6XIT

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Cerebellum; testes; cortex and substentia nigra.

DOI ID

10.1016/0014-5793(94)01007-2; 10.1074/jbc.270.48.28660; 10.1006/bbrc.1996.0050; 10.1006/geno.1998.5369; 10.1038/ng1095-126; 10.1016/j.cell.2010.12.001

RefSeq

NP_001020756.1; NP_001020761.1; NP_034736.2; XP_011244406.1